In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined “perioperative tumour growth” and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget1Sir James Paget (1814–1899) was a surgeon and physiologist who is widely held (along with Rudolph Virchow) to be the father of the science of pathology. (...) Paget described Paget's disease of the nipple as well as Paget's disease of bone. himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host–tumour interactions that may occur during the perioperative period. BioEssays 28: 433–437, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

Woodward's long awaited book is an attempt to construct a comprehensive account of causation explanation that applies to a wide variety of causal and explanatory claims in different areas of science and everyday life. The book engages some of the relevant literature from other disciplines, as Woodward weaves together examples, counterexamples, criticisms, defenses, objections, and replies into a convincing defense of the core of his theory, which is that we can analyze causation by appeal to the notion of manipulation.

Argues that Wittgenstein's early ethical notion of agreement with the world pivoted to become his later therapeutic notion of agreement with living forms, which satisfies the conditions necessary for a full therapeutic philosophy.

If the contemporary rebirth of the ontological argument had its conception in Norman Malcolm's discovery of a second Anselmian argument it had its full-term delivery as a healthy philosophical progeny with Alvin Plantinga's sophisticated modal version presented in the tenth chapter of The Nature of Necessity. This latter argument has been the centre of a huge body of literature over the last fifteen years, and deservedly so. One is impressed that this version of Anselm's jewel is valid and sound if (...) any is. (shrink)

An introduction to Catholic theological ethics through the lens of its historical development from the beginning of the church until today.

Philosophy studies the relation between random, routine, and reflective thought and action. It is in essence the reflective study of routine. No one can survive a random world, but a routine world will generate the same randomness it is intended to avoid owing to the inevitable errors associated with routines. The prime function of reflective inquiry is to identify and explain the logical foundation of these errors. While governments depend on strict routine to prevent anarchy, it is only with the (...) maintenance and adaptive revision of those routines that they are able to serve that purpose. Thus philosophy is essential even to preserve routine, aside from facilitating the building of better routines. To advance global understanding philosophers need to use informal means to communicate to all people everywhere the distinction between randomness and routine, and the transcending of routine by reflective study. I add a concluding note of advocacy for UNESCO’s Strategy on Philosophy. (shrink)

Public health ethics, like the field of public health it addresses, traditionally has focused more on practice and particular cases than on theory, with the result that some concepts, methods, and boundaries remain largely undefined. This paper attempts to provide a rough conceptual map of the terrain of public health ethics. We begin by briefly defining public health and identifying general features of the field that are particularly relevant for a discussion of public health ethics.Public health is primarily concerned with (...) the health of the entire population, rather than the health of individuals. Its features include an emphasis on the promotion of health and the prevention of disease and disability; the collection and use of epidemiological data, population surveillance, and other forms of empirical quantitative assessment; a recognition of the multidimensional nature of the determinants of health; and a focus on the complex interactions of many factors—biological, behavioral, social, and environmental—in developing effective interventions. (shrink)

TWENTIETH-CENTURY CATHOLIC MORAL THEOLOGIANS HAVE ABANDONED their long-standing primary task of being teachers of priests who need specific interpretations of the law to hear confessions properly. By 1965 they had become guardians of the personal consciences of lay people seeking to become disciples of Christ. This shift was occasioned by a sustained debate between manualists and revisionists in which they argued about the primary locus of moral theology, about the locus of moral truth, and about the objectivity of moral truth.

The topics covered in this volume, originally published in 1973, include the need for a more adequate concept or definition of education, the issue of whether indoctrination is compatible with education, particularly with moral education, and the processes of judging the merits of different approaches to aesthetic education. Two contributors present complementary analyses of the relations between freedom as a characteristic of institutions and the process of learning to be a free man. There is discussion of the neglected subject of (...) rights and duties in education, with special emphasis on the question of a universal right to education. The volume concludes with papers on the relevance of philosophy to the practical judgments of educators and to education as a field of study. (shrink)

Book reviewed in this article: How Brave a New World? Dilemmas in Bioethics. By Richard A. McCormick. Notes on Moral Theology, 1965 through 1980. By Richard A. McCormick.

From sex abuse scandals to the treatment of adjunct professors, universities are mired in thorny ethical questions. In this book, Keenan exposes the problems that arise from the lack of professional ethics in the college environment, then proposes concrete solutions for issues ranging from athletics and adjuncts to tuition and salaries.

The latter quality can be cultivated by the metaphysician through considering the intimate link between signification and being. The impossibility of separating the two is highlighted by the fact that even "non-being" is significant as a sign of the simple negative judgment, x is not. For this sign assuredly is. And a "square circle," mathematically and physically nonexistent, has the "being" of an incompatible conjunction of signs severally significant.